Cleopatra (69-30 BC), queen of Egypt (51-30 BC), celebrated for her love affairs with Julius Caesar and Mark Antony. In 51 BC, on the death of her father, King Ptolemy XII Auletes, Cleopatra and her brother Ptolemy XIII succeeded jointly to the throne. In the third year of their reign Ptolemy drove Cleopatra into exile. Roman general Julius Caesar arrived in Alexandria, became Cleopatra's lover, and returned her to the throne, after which Cleopatra lived in Rome as Caesar's mistress. After Caesar's assassination in 44 BC, Cleopatra returned to Egypt. Roman general Mark Antony then fell in love with Cleopatra and moved to Egypt. Later Antony returned to Rome, where he married Octavia, a sister of Caesar's heir, Octavian, later Emperor Augustus. When Antony went to the East as commander of an expedition against the Parthians in 36 BC, he and Cleopatra reunited. Following Antony's victory over the Parthians, Antony and Cleopatra lived in Egypt until 32 BC, when Octavian declared war against them. Following the Battle of Actium in 31 BC, Cleopatra and Antony fled to Alexandria, where they both committed suicide.

Another source adds:

In the springtime of 51 BC, Ptolemy Auletes died and left his kingdom in his will to his eighteen
  year old daughter, Cleopatra, and her younger brother Ptolemy XIII who was twelve at the
  time. Cleopatra was born in 69 BC in Alexandria, Egypt. She had two older sisters, Cleopatra
  VI and Berenice IV as well as a younger sister, Arsinoe IV. There were two younger brothers
  as well, Ptolemy XIII and Ptolemy XIV. It is thought that Cleopatra VI may have died as a
  child and Auletes had Berenice beheaded. At Ptolemy Auletes' death, Pompey, a Roman
  leader, was left in charge of the children. During the two centuries that preceded Ptolemy
  Auletes death, the Ptolemies were allied with the Romans. The Ptolemies' strength was failing
  and the Roman Empire was rising. City after city was falling to the Roman power and the
  Ptolemies could do nothing but create a pact with them. During the later rule of the Ptolemies,
  the Romans gained more and more control over Egypt. Tributes had to be paid to the Romans
  to keep them away from Egypt. When Ptolemy Auletes died, the fall of the Dynasty appeared
  to be even closer.

According to Egyptian law, Cleopatra was forced to have a consort, who was either a brother
  or a son, no matter what age, throughout her reign. She was married to her younger brother
  Ptolemy XIII when he was twelve, however she soon dropped his name from any official
  documents regardless of the Ptolemaic insistence that the male presence be first among
  co-rulers. She also had her own portrait and name on coins of that time, ignoring her brother's.
  When Cleopatra became co-regent, her world was crumbling down around her. Cyprus,
  Coele-Syria and Cyrenaica were gone. There was anarchy abroad and famine at home.
  Cleopatra was a strong-willed Macedonian queen who was brilliant and dreamed of a greater
  world empire. She almost achieved it. Whether her way of getting it done was for her own
  desires or for the pursuit of power will never be known for certain. However, like many
  Hellenistic queens, she was passionate but not promiscuous. As far as we know, she had no
  other lovers other than Caesar and Antony. Many believe that she did what she felt was
  necessary to try to save Alexandria, whatever the price.

By 48 BC, Cleopatra had alarmed the more powerful court officials of Alexandria by some of
  her actions. For instance, when mercenaries killed the Roman governor of Syria's sons when they
 came to ask for her assistance for their father against the Parthians she send them for trial to Syria.
 A group of men led by
  Theodotus, the eunuch Pothinus and a half-Greek general, Achillas, overthrew her in favor of
  her younger brother. They believed him to be much easier to influence and they became his
  council of regency. Cleopatra is thought to have fled to Thebaid. Between 51 and 49 BC,
  Egypt was suffering from bad harvests and famine because of a drought which stopped the
  much needed Nile flooding. Ptolemy XIII signed a decree on October 27, 50 BC which
  banned any shipments of grain to anywhere but Alexandria. It is thought that this was to
  deprive Cleopatra and her supporters who were not in Alexandria. Regardless, she started an
  army from the Arab tribes which were east of Pelusium. During this time, she and her sister
  Arsinoe moved to Syria. They returned by way of Ascalon which may have been Cleopatra's
  temporary base.

In the meantime, Pompey had been defeated at Pharsalus in August of 48 BC. He headed for
  Alexandria hoping to find refuge with Ptolemy XIII, of whom Pompey was a senate-appointed
  guardian. Pompey did not realize how much his reputation had been destroyed by Pharsalus
  until it was too late. He was murdered as he stepped ashore on September 28, 48 BC. The
  young Ptolemy XIII stood on the dock and watched the whole scene. Four days later, Caesar
  arrived in Alexandria. He brought with him thirty-two hundred legionaries and eight hundred
  cavalry. He also brought twelve other soldiers who bore the insignia of the Roman government
  who carried a bundle of rods with an ax with a blade that projected out. This was considered a
  badge of authority that gave a clear hint of his intentions. There were riots that followed in
  Alexandria. Ptolemy XIII was gone to Pelusium and Caesar placed himself in the royal palace
  and started giving out orders. The eunuch, Pothinus, brought Ptolemy back to Alexandria.
  Cleopatra had no intentions of being left out of any deals that were going to be made. She had
  herself smuggled in through enemy lines rolled in a carpet. She was delivered to Caesar. Both
  Cleopatra and Ptolemy were invited to appear before Caesar the next morning. By this time,
  she and Caesar were already lovers and Ptolemy realized this right away. He stormed out
  screaming that he had been betrayed, trying to arouse the Alexandrian mob. He was soon
  captured by Caesar's guards and brought back to the palace. It is thought that Caesar had
  planned to make Cleopatra the sole ruler of Alexandria. He thought she would be a puppet for
  Rome.

The Alexandrian War was started when Pothinus called for Ptolemy XIII's soldiers in
  November and surrounded Caesar in Alexandria with twenty thousand men. During the war,
  parts of the Alexandrian Library and some of the warehouses were burned. However, Caesar
  did manage to capture the Pharos lighthouse, which kept his control of the harbor. Cleopatra's
  sister, Arsinoe, escaped from the palace and ran to Achillas. She was proclaimed the queen by
  the Macedonian mob and the army. Cleopatra never forgave her sister for this. During the
  fighting, Caesar executed Pothinus and Achillas was murdered by Ganymede. Ptolemy XIII
  drowned in the Nile while he was trying to flee.

  Because of his death, Cleopatra was now the sole ruler of Egypt. Caesar had restored her
  position, but she now had to marry her younger brother Ptolemy XIV, who was eleven years
  old. This was to please the Alexandrians and the Egyptian priests. Surely Caesar went through
  all of this trouble for more than his infatuation with the queen of Egypt. It must have been out of
  arrogance and his desire to get his hands on Egypt's vast resources. However, Cleopatra's
  intelligence and inheritance did have some influence as well. In what must have been very
  calculated on his part, she became pregnant rather quickly. For him to have a son to carry the
  throne was very appealing to him. Caesar and Cleopatra took an extended trip up the Nile for
  about two months. They stopped in Dendara where Cleopatra was worshipped as a Pharaoh.
  Caesar would never have this honor. Caesar only left the boat to attend important business in
  Syria just a few weeks before the birth of their son, Caesarion (Ptolemy Caesar) who was
  born on June 23, 47 BC.

 During July of the year 46 BC, Caesar returned to Rome. He was given many honors and a
  ten-year dictatorship. These celebrations lasted from September to October and he brought
  Cleopatra over, along with her entourage. The conservative Republicans were very offended
  when he established Cleopatra in his home. Her social manners did not make the situation any
  better. She upset many. Cleopatra had started calling herself the New Isis and was the subject
  of much gossip. She lived in luxury and had a statue made of gold placed by Caesar, in the
  temple of Venus Genetrix . Caesar also openly claimed Caesarion as his son. Many were upset
  that he was planning to marry Cleopatra regardless of the laws against bigamy and marriages to
  foreigners.

  However, on the Ides of March of 44 BC, all of that came to an end. Caesar was assassinated
  outside the Senate Building in Rome. He was killed in a conspiracy by his Senators. Many of
  the Senators thought he was a threat to the republic's well-being. It was thought that Caesar
  was making plans to have himself declared king. After Caesar's murder, Cleopatra fled Rome
  and returned home to Alexandria. Caesar had not mentioned Cleopatra or Caesarion in his
  will. She felt her life, as well as that of her child, was in great danger.

 Upon returning to Alexandria, she had her consort, Ptolemy XIV, assassinated and established
  Caesarion as her co-regent at the age of four. She found Egypt suffering from plagues and
  famine. The Nile canals had been neglected during her absence which caused the harvests to
  be bad and the inundations low. The bad harvests continued from 43 until 41 BC. Trying to
  help secure recognition for Caesarion with Caesar's former lieutenant Dolabella, Cleopatra sent
  Dolabella the four legions that Caesar had left in Egypt. Cassius captured the legions which
  caused Dolabella to commit suicide at Laodicea during the summer of 43 BC. She was
  planning to join Mark Antony and Octavian (who became Augustus) with a large fleet of ships
  after Dolabella's death, but was stopped by a violent storm.

  Cleopatra watched in the time that followed, who would be the next power in Rome. After
  Brutus and Cassius had been killed and Antony, Octavian and Lepidus were triumphant,
  Cleopatra knew which one she would have to deal with. Octavian went back to Italy very ill,
  so Antony was the one to watch. Her son gained his right to become king when Caesar was
  officially divinized in Rome on January 1, 42 BC. The main object was the promotion of
  Octavian, but the triumvirs knew of Cleopatra's aid to Dolabella.

Cleopatra was invited by Mark Antony to Tarsus in 41 BC. She already knew enough about
  him to know how to get to him. She knew about his limited strategic and tactical abilities, his
  blue blood, the drinking, his womanizing, his vulgarity and his ambition. Even though Egypt was
  on the verge of economic collapse, Cleopatra put on a show for Mark Antony that even
  Ptolemy Philadelphos couldn't have done better. She sailed with silver oars, purple sails with
  her Erotes fanning her and the Nereid handmaids steering and she was dressed as Aphrodite,
  the goddess of love. This was a very calculated entrance; considered vulgar by many. It was a
  vulgar display to attract the attention of a vulgar man. Mark Antony loved the idea of having a
  blue-blooded Ptolemy woman. His former mistress as well as his current wife, Fulvia, were
  merely middle class.

  Cleopatra and Antony spent the winter of 41 to 40 in Alexandria. According to some sources,
  Cleopatra could get out of him whatever she wanted, including the assassination of her sister,
  Arsinoe. Cleopatra may not have had so much influence over him later on. He took control of
  Cyprus from her. Actually it may have been Cleopatra who was the exploited one. Antony
  needed money and Cleopatra could be generous when it benefited her as well.

  In the spring of 40 BC, Mark Antony left Cleopatra and returned home. He did not see her for
  four years. Antony's wife, Fulvia had gotten into a serious movement against Octavian over
  veterans' allotments of land. She fled to Greece and had a bitter confrontation with Antony.
  She became ill and died there. Antony patched things up with Octavian that same autumn by
  marrying Octavian's sister, Octavia. She was a beautiful and intelligent woman who had been
  recently widowed. She had three children from her first marriage. In the meantime, Cleopatra
  had given birth to twins, one boy and one girl, in Alexandria. Antony's first child by Octavia
  was a girl. Had Octavia given him a son, things might have turned out different. Antony kept
  the idea of the treasures of the Ptolemies and how much he wanted it. When he finally did get
  the treasures, the standard interest rate in Rome fell from 12 percent to 4.

Mark Antony left Italy and went to deal with the Parthians. Octavia had just had another
  daughter and went with him just as far as Corcyra. He gave her the excuse that he did not want
  to expose her to the dangers of the battles and sent her home. He told her that she would be
  more use to him at home in Rome keeping peace with her brother, Octavian. However, the
  first thing that he did when he reached Antioch, was to send for Cleopatra. Their twin children
  were officially recognized by Antony and were given the names of Alexander Helios and
  Cleopatra Selene. Mark Antony gave her much land which was very essential to Egypt. He
  gave her Cyprus, the Cilician coast, Phoenicia, Coele-Syria, Judea and Arabia. This allowed
  Egypt to be able to build ships from the lumber from Cilician coast. Egypt then built a large
  fleet. Antony had planned a campaign against the Parthians. He obviously needed Cleopatra's
  support for this and in 36 BC, he was defeated. He became more indebted to her than ever.
  They had just had a third child.

  On their return to Syria, she met him and what was left of his army, with food, clothing and
  money. Early in 35 BC, he returned to Egypt with her. Antony's wife, Octavia was in Athens
  with supplies and reinforcements waiting for her husband. He sent her a letter telling her to not
  come any further. Her brother, Octavian, tried to provoke Antony into a fight. Octavian would
  release troops as well as ships to try to force Antony into a war, which, by this time was almost
  inevitable. Antony might have been able to patch things up with Octavia and her brother had he
  returned to Rome in 35 BC. Cleopatra probably did her best to keep him in Alexandria.
  Octavia remained completely loyal to Antony through all of this.

In 34 BC, Antony had a campaign into Armenia, which was successful and financially
  rewarding. He celebrated his triumph with a parade through Alexandria with Cleopatra
  presiding over as the New Isis. Antony presented himself as the New Dionysus as part of his
  dream of the Graeco-Roman rule. Within a few days, a more political ceremony took place in
  which the children were given their royal titles with Antony sitting on the throne as well.
  Ptolemy XV (Caesarion) was made the co-ruler with his mother and was called the King of
  Kings. Cleopatra was called the Queen of Kings, which was a higher position than that of
  Caesarion's. Alexander Helios, which meant the sun, was named Great King of the Seleucid
  empire when it was at its highest. Cleopatra Selene, which meant the moon, was called Queen
  of Cyrenaica and Crete. Cleopatra and Antony's son, Ptolemy Philadelphos was named King
  of Syria and Asia Minor at the age of two. Cleopatra had dreams of becoming the Empress of
  the world. She was very close to achieving these dreams and her favorite oath was, "As surely
  as I shall yet dispense justice on the Roman Capital."

In 32 to 31 BC, Antony finally divorced Octavia. This forced the Western part of the world to
  recognize his relationship with Cleopatra. He had already put her name and face on a Roman
  coin, the silver denarii. The denarii was widely circulated throughout the Mediterranean. By
  doing this, Antony's relationship with the Roman allegiance was ended and Octavian decided
  to publish Antony's will. Octavian then formally declared war against Cleopatra. Antony's
  name was nowhere mentioned in the official declaration. Many false accusations were made
  against Cleopatra saying that she was a harlot and a drunken Oriental. These accusations were
  most likely made out of fear of Cleopatra and Antony. Many probably thought that the New
  Isis would prevail and that Antony would start up a new wave of world conquest and rule in a
  co-partnership from Alexandria. However, Octavian's navy severely defeated Antony in
  Actium, which is in Greece, on September 2, 31 BC. Octavian's admiral, Agrippa, planned
  and carried out the defeat. In less than a year, Antony half-heartedly defended Alexandria
  against the advancing army of Octavian. After the defeat, Antony committed suicide by falling
  on his own sword in 30 BC.

After Antony's death, Cleopatra was taken to Octavian where her role in Octavian's triumph
  was carefully explained to her. He had no interest in any relationship, negotiation or
  reconciliation with the Queen of Egypt. She would be displayed as a slave in the cities she had
  ruled over. She must have had memories of her sister, Arsinoe, being humiliated in this way.
She would not live this way, so she had an asp, which was an Egyptian cobra, brought to her
  hidden in a basket of figs. She died on August 12, 30 BC at the age of 39. The Egyptian
  religion declared that death by snakebite would secure immortality. With this, she achieved her
  dying wish, to not be forgotten. The only other ruler to cast a shadow on the fascination with
  Cleopatra was Alexander who was another Macedonian. After Cleopatra's death, Caesarion
  was strangled and the other children of Cleopatra were raised by Antony's wife, Octavia.

 Her death was the mark of the end of the Egyptian Monarchs. The Roman Emperors came
  into to rule in Egypt. The Ptolemies were Macedonian in decent, but ruled as Egyptians, as
  Pharaohs. Cleopatra was the last Pharaoh of Egypt.

What is often not associated with Cleopatra was her brilliance and her devotion to her country.
  She was a quick-witted woman who was fluent in nine languages, however, Latin was not one
  of them. She was a mathematician and a very good businesswoman. She had a genuine respect
  for Caesar, whose intelligence and wit matched her own. Antony on the other hand almost
  drove her insane with his lack of intelligence and his excesses. She dealt with him and made the
  most of what she had to do. She fought for her country. She had a charismatic personality, was
  a born leader and an ambitious monarch who deserved better than suicide.

Ancient Sources: Plutarch: Antony, Caesar
Plutarch: Cleopatra (Diotima) -- An excerpt from Life of Mark Anthony.
 

Chronology of Cleopatra's Life   BC 69     Birth of Cleopatra BC 48     Caesar restores Cleopatra on the Egyptian throne BC 46-44  Cleopatra resides in Rome BC 44-40  Elimination of Caesar's assassins BC 44     Assassination of Caesar BC 43     Formation of the triumvirate:               Antony - Octavian (Augustus) - Lepidus BC 43-42  Victory of the triumvirate over Caesar's assassins  at Philippi           Definite death of the republic           Antony in charge of reorganizing the Orient BC 42     Dionysiac entry of Antony at Ephesus BC 41     Meeting between Antony and Cleopatra at Tarsus                 The Roman General follows her to Egypt   BC 40-34  Formation of the two blocks BC 40     Treaty between Antony, Octavian, and Lepidus           The triumvirate rule Rome jointly           Partition of the Mediterranean              - Octavian: The western provinces                          (Spain, Sardinia, Sicily,                          Transalpine Gaul, Narbonne)              - Antony  : The eastern provinces                          (Macedonia, Asia, Bithynia,                          Cilicia, Syria)              - Lepidus : Africa (Tunisia and Algeria) BC 36     Elimination of Lepidus           Octavian controls Africa and becomes the               effective ruler of Rome           Parthian campaign of Marc Antony BC 34     Organization of the "Antonian Orient"           Triumph of Alexandria           Donations Ceremony   BC 43-30  Fall and death of Cleopatra and Marc Antony           Victory of the West over the East   BC 32     Western provinces pledge allegiance to Octavian           Declaration of war on Cleopatra           Antony and his allies gather on the Island of Samos BC 31     Battle of Actium and victory of Octavian           Antony and Cleopatra seek refuge at Alexandria BC 30     Victory of Octavian at Alexandria           Suicide of Antony and Cleopatra           Egypt becomes a Roman province